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SANTA CLARA, Calif. — The Green Bay Packers are in wait-and-see mode with Davante Adams.

The Packers took the entire week to determine if the second-year receiver could play through his aggravated left ankle injury. The Packers first listed Adams as questionable, but decided to play it safe and hold him out of Sunday’s 17-3 win over San Francisco at Levi's Stadium.

The Packers receiver sprained his ankle two weeks ago against Seattle, but returned in the second half. He played the following week on limited practice before aggravating it on the third offensive play in last Monday’s 38-28 win over Kansas City.

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It all led to him missing his first NFL game Sunday. His availability for next week's game against St. Louis and going forward will depend on how well the ankle responds to treatment.

“Didn’t really know for sure,” said Adams of his chances of playing against the 49ers. “I’m just trying to pretty much take it day-by-day. You want to be smart on it. The last thing I want to do is — I came back last time and re-aggravated it so I’m just trying to be smart.”

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Adams remains adamant he didn't suffer a high-ankle sprain despite reports this week to the contrary. He said his current situation pales in comparison to the high-ankle sprain he suffered in high school, which doubles as the last ankle injury he’s dealt with.

His absence left the Packers thin at receiver. They promoted Jared Abbrederis before the game, but the offense centered primarily on Randall Cobb, James Jones and Ty Montgomery. There were positives — Jones had five catches for 98 yards — but drops were also an issue for the unit Sunday.

Adams was seen wearing a boot on the foot in the locker room early this week, but has since ditched it and doesn't plan to utilize it going forward. Credited as the team’s offseason MVP, the 6-foot-1, 215-pound receiver has nine catches for 92 yards in three games.

The tricky thing with ankle sprains is they're somewhat subjective. Where it's nearly impossible to play through a broken bone, sometimes you feel you can do more than you actually can when dealing with a sprain. For now, Adams’ focus is on getting better.

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“It’s a little frustrating because you kind of want to test it a little bit,” Adams said. “The bone, it tells you if it’s broken you’re not going. With this, it’s one of those things you can try to fight through, but you don’t want to do what I did. I came back in the Chiefs game and re-hurt it. The biggest thing is making sure I’m being smart with it and keep going and jeopardize later on in the season pretty much.”

Cobb, who’s playing through a shoulder sprain, said he didn’t re-injure his left shoulder near the end of the first half when he fell at the end of an incompletion in the end zone. He missed one play and returned to the game. At first glance, there were no significant injuries.

“I wouldn’t have went back in the game if I had re-hurt it,” said Cobb, who had five catches for 44 yards.

whodkiew@pressgazettemedia.com and follow him on Twitter @WesHod.

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