Seattle Seahawks vs. San Francisco 49ers picks, predictions: Who wins NFL Week 4 game?
The Seattle Seahawks and San Francisco 49ers face off on Sunday in a Week 4 NFL game.
Which team will get the victory?
Check out these NFL Week 4 picks and predictions for the game, which can be seen at 1:05 p.m. MST time on Fox.
The 49ers are a 3.5-point favorite in the game.
More NFL Week 4 picks, predictions:
- Jaguars vs. Bengals | Titans vs. Jets | Panthers vs. Cowboys
- Chiefs vs. Eagles | Giants vs. Saints | Browns vs. Vikings
- Lions vs. Bears | Texans vs. Bills | Washington vs. Falcons
- Colts vs. Dolphins | Seahawks vs. 49ers | Cardinals vs. Rams
- Steelers vs. Packers | Ravens vs. Broncos | Bucs vs. Patriots
- Raiders vs. Chargers | Week 4: TV | Odds, lines | Rankings
Pro Football Network: 49ers 24, Seahawks 21
Ben Rolfe writes: "The 49ers will be devastated not to be 3-0 after a last-second loss to the Packers. Staying at home for Week 4, they should have the advantage in this one, but divisional games are always ultra-competitive. The 49ers appear to be the better team, and their running game should take over."
Sportsnaut: 49ers 31, Seahawks 23
Andrew Buller-Russ writes: "Following a vicious Super Bowl hangover, San Francisco has proven that it’s back in a big way. Numerous key starters return from injuries, including starting QB Jimmy Garoppolo and pass-rusher Nick Bosa. This Seahawks D won’t be able to stop San Francisco’s talented offense."
Sportsnaut: 49ers 24, Seahawks 20
Vincent Frank writes: "Kyle Shanahan is a mere 1-3 at home against Seattle at home against Seattle since taking over as the 49ers' head coach. That must change if San Francisco wants to rebound following an injury-plagued 2020 season. The good news? These 49ers match up extremely well against the Seahawks -- primarily on defense. A healthy Nick Bosa returning with All-Pro linebacker Fred Warner should do just enough against Russell Wilson and Co. to come out on top at home in this Week 4 matchup. Regardless, it will be a telling early-season divisional game for both squads."
Gambling News: Go with the 49ers against the Seahawks
Jessie Carter writes: "The Niners had a one-point lead until the very last second of the game against the Green Bay Packers, but then placekicker Mason Crosby scored a field goal. Nevertheless, San Francisco players should feel proud of their performance against one of the best offenses in the league. They should also feel optimistic ahead of Week 4, as they’re now taking on a team that doesn’t seem as lethal as the Packers. The Seahawks did score a lot of points against the Niners in 2020 (60 in two games), but this time, San Francisco’s defense looks much stronger. After all, this year, they got Nick Bosa in the team. One of the NFL’s best edges had to miss 14 games in 2020 due to an injury, but this season, he’s back and he’s been phenomenal thus far."
CBS Sports: Seahawks 26, 49ers 23
Cody Benjamin writes: "Shanahan dials up a heavy ground game to control the clock, but once again, the 49ers are stuck in a nail-biter with a great QB. Russell Wilson, meanwhile, wins the final stretch thanks in part to his superior receiving corps, headlined by DK Metcalf."
Draft Kings: 49ers will cover in Week 4 game against Seahawks
David Fucillo writes: "I’m a 49ers homer, so take my pick with a grain of salt. I’d say stay away from the spread on this one entirely, but if it stays at a field goal or less, lay it with the home team. On the other hand, the under is intriguing. Neither defense is playing great, but these two teams play close ones. The rosters have changed, but these teams have reached this current total twice in the past nine matchups dating back to the 2017 season. They can play some serious grinders."
FiveThirtyEight.com: 49ers have a 62% win probability
The site gives the Seahawks a 38% win probability.
ESPN: 49ers have a 56.4% chance to win
The site's Football Power Index gives the Seahawks a 43.3% to pick up the victory.
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