Indianapolis Colts vs. San Francisco 49ers picks, predictions: Who wins NFL Week 7 game?

Jeremy Cluff
Arizona Republic
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The Indianapolis Colts and San Francisco 49ers face off on Sunday in a Week 7 NFL game.

Which team will get the victory?

Check out these NFL Week 7 picks and predictions for the game, which can be seen at 5:20 p.m. MST time on NBC.

The 49ers are a 4.5-point favorite in the game.

More NFL Week 7 picks, predictions:

Pro Football Network: 49ers 24, Colts 17

Ben Rolfe writes: "Credit the Colts for fighting and keeping themselves even marginally alive in the AFC, but this game is worlds away from their matchup with the Texans in Week 6. The 49ers will be rested and have an ideal game plan for pulling Indianapolis’ defense all over the field. Throw in the Colts’ banged-up offensive line and this could get ugly. Indy’s best hope is that the 49ers come out a little rusty from their bye week."

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Sportsnaut: 49ers 20, Colts 17

Matt Johnson writes: "A matchup between two teams that are likely a great quarterback away from Super Bowl contention, With the 49ers playing at home and boasting the better defense and coaching staff, this projects as another loss on the Colts schedule."

CBS Sports: Colts 23, 49ers 14

Jared Dubin writes: "That's more like it. Indy goes on the road to San Francisco, beating the Niners on Sunday Night Football."

Colts Wire: Colts 19, 49ers 17

Kevin Hickey writes: "Kyle Shanahan has his quarterback in Trey Lance but this is going to be one of those weird games where the rushing attacks for each team take over. The Colts win out in prime time and Eric Fisher’s first game back from the PUP list has an impact."

NFL Week 7:

Can Carson Wentz lead the Indianapolis Colts past the San Francisco 49ers in Week 7 of the 2021 NFL season?

Draft Kings: 49ers will cover in Week 7 game vs. Colts

Cole Huff writes: "There’s no telling which quarterback will take the opening or closing snaps for the Niners in this Week 7 matchup with the Colts. From the looks of it, it’ll be Jimmy Garoppolo, which gives the Niners’ passing attack a bit more juice. Indianapolis has played well, though, over the past couple of weeks and should make for a tough out. Still, I like San Francisco at home after an extra week of rest and preparation."

Sportsnaut: Colts 23, 49ers 17

Vincent Frank writes: "Whether the San Francisco 49ers start Trey Lance or Jimmy Garoppolo, this figures to be a low-scoring game. Both teams want to win with their defense and controlling the clock. Long drives, plenty of field goals and Carson Wentz making just enough plays in the final minutes to secure a victory."

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The site gives the Colts a 34% win probability in the NFL Week 7 game.

ESPN: 49ers have a 63.8% chance to win

The site's Football Power Index gives the Colts a 36% chance to pick up the victory in the Week 7 NFL game.

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