Tennessee Titans vs. Indianapolis Colts picks, predictions: Who wins NFL Week 4 game?

The Tennessee Titans and Indianapolis Colts play on Sunday in a game on the NFL Week 4 schedule.
Which team will get the victory?
Check out these NFL Week 4 picks and predictions for the game, which can be seen at 10 a.m. MST on Fox.
The Colts are a 3.5-point favorite in the game.
NFL Week 4 picks, predictions:
- Dolphins vs. Bengals | Vikings vs. Saints | Browns vs. Falcons
- Bills vs. Ravens | Commanders vs. Cowboys | Titans vs. Colts
- Seahawks vs. Lions | Chargers vs. Texans | Bears vs. Giants
- Jaguars vs. Eagles | Jets vs. Steelers | Cardinals vs. Panthers
- Patriots vs. Packers | Broncos vs. Raiders | Chiefs vs. Bucs
- Rams vs. 49ers | The Republic's Week 4 NFL predictions
The Arizona Republic: Colts 28, Titans 27
Jeremy Cluff writes: "Both of these teams got much-needed wins in Week 3 and both need a win in Week 4 to keep pace in the division. We'll take the home team here, just barely."
Draft Kings: Go with the Titans with the points vs. Colts
It writes: "Indianapolis had dominated this matchup for a long time but the Titans have found a way to flip the script over the last two seasons. Tennessee is 4-1 in the last five games against Indianapolis, so take the points and the Titans in Week 4."
- Dolphins vs. Bengals | Vikings vs. Saints | Browns vs. Falcons
- Bills vs. Ravens | Commanders vs. Cowboys | Titans vs. Colts
- Seahawks vs. Lions | Chargers vs. Texans | Bears vs. Giants
- Jaguars vs. Eagles | Jets vs. Steelers | Cardinals vs. Panthers
- Patriots vs. Packers | Broncos vs. Raiders | Chiefs vs. Bucs
- Rams vs. 49ers | Spreads, lines, over/unders | Super Bowl
FanDuel: Bet the Colts on the moneyline against Titans
Adam Taylor McKillop writes: "The Colts are clear favorites playing at home in Week 4. That's evidenced by both the opening betting lines and ESPN's FPI metric. It all comes down to the success of Derrick Henry. Unfortunately, the Colts pose one of the best run-defense units in the NFL, ranking second in Football Outsiders' DVOA metric. Indy slows down Henry enough to hold onto a win, but not enough to cover even a field goal spread."
Bookies.com: Take the Colts to cover against Titans
Bill Speros writes: "This season, the Titans and Colts play twice in the month of October. Both teams are looking up at the Jaguars in the AFC South standings. The Colts have the edge this week given that they are home and riding an emotional high following an upset win over Mahomes and the Chiefs. Matt Ryan finally got his offense moving just enough to edge out Kansas City. The Titans were more relieved than anything else after beating the woeful Raiders. Mike Vrabel's job is safe for another week. Wager accordingly for your NFL Week 4 best bets."
More:NFL Week 4 schedule, television information: How to watch Week 4 NFL games
Sports Betting Dime: Colts 18.7, Titans 11.6
The site's formula predicts that the Colts will beat the Titans in the NFL Week 4 game.
Fansided: Take the under in Colts vs. Titans game
Joseph Summers writes: "Due to the uncertainty around the Colts’ offense, and Tennessee’s own offensive issues, I’m backing the under. It’s hit in each of Indianapolis’ last eight games and both teams’ desire to establish the run means the likely game script results in a low-scoring affair. Trust the defense and stick with the under in a critical AFC South battle."
More:NFL power rankings Week 4: Philadelphia Eagles, Miami Dolphins, Jacksonville Jaguars rise
Betsided: Colts will cover in NFL Week 4 game vs. Titans
Ian MacMillan writes: "The Titans continue to rely on their running game for their offense. 47.62% of their called plays are run pays, which is the 7th highest rate in the NFL. They'll struggle to stick to that game plan on Sunday, as no team allowed fewer yards per carry than the Colts, who are keeping team to averaging 2.6 yards per rush. I trust Matt Ryan and the Colts to get the job done against an injured and depleted Titans roster."
ESPN: Colts have a 61% chance to win the game
The site's Football Power Index gives the Titans a 38.6% shot at picking up the victory.
More:NFL Week 4 odds: Point spreads, moneylines, over/under for every Week 4 NFL game
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on Twitter @Jeremy_Cluff.
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