Detroit Lions vs. New England Patriots picks, predictions: Who wins NFL Week 5 game?

The Detroit Lions and New England Patriots play on Sunday in a game on the NFL Week 5 schedule.
Which team will get the victory?
Check out these NFL Week 5 picks and predictions for the game, which can be seen at 10 a.m. MST on Fox.
The Patriots are a 2.5-point favorite in the game.
NFL Week 5 picks, predictions:
- Colts vs. Broncos | Giants vs. Packers | Steelers vs. Bills
- Chargers vs. Browns | Texans vs. Jaguars | Bears vs. Vikings
- Lions vs. Patriots | Seahawks vs. Saints | Dolphins vs. Jets
- Falcons vs. Bucs | Titans vs. Commanders | 49ers vs. Panthers
- Eagles vs. Cardinals | Cowboys vs. Rams | Bengals vs. Ravens
- Raiders vs. Chiefs | For subscribers: The Republic's NFL picks
The Arizona Republic: Lions 34, Patriots 21
Jeremy Cluff writes: "The Lions' offense has been great this season, it's the defense that has huge question marks. But New England has questions at QB."
Bookies.com: Take the Patriots in game vs. Lions
Bill Speros writes: "The Lions won hearts and minds last season by going 11-6 ATS despite a 3-13 record straight up. Their brand grew even larger thanks to the dynamism of coach Dan Campbell on "Hard Knocks" this past summer. Now, just imagine the Patriots and Bill Belichick on “Hard Knocks.” Each episode would run about 48 seconds. This game remains a pick 'em depending on where you shop. The Patriots are back to their pre-Brady form and celebrating "Moral Victories" - such as taking the Packers to overtime behind rookie QB Bailey Zappe before losing 27-24. Look for the Patriots to get an old-fashioned victory on the scoreboard."
- Colts vs. Broncos | Giants vs. Packers | Steelers vs. Bills
- Chargers vs. Browns | Texans vs. Jaguars | Bears vs. Vikings
- Lions vs. Patriots | Seahawks vs. Saints | Dolphins vs. Jets
- Falcons vs. Bucs | Titans vs. Commanders | 49ers vs. Panthers
- Eagles vs. Cardinals | Cowboys vs. Rams | Bengals vs. Ravens
- Raiders vs. Chiefs | Spreads, lines, over/unders | Super Bowl
ESPN: Patriots have a 51.5% win probability
The site's Football Power Index gives the Lions a 47.9% chance to win the NFL Week 5 game.
Draft Kings: Go with the Lions with the points vs. Patriots
It writes: "The uncertainty under center hinders the scoring potential for the Patriots, no matter how well Bill Belichick and staff can formulate an offensive strategy. Meanwhile, the Lions entered Week 4 as the second-highest scoring team in the NFL (31.7 PPG), and if they welcome back some offensive weapons that were absent on Sunday it’s clear they have the talent advantage. At the very least, Detroit should keep this a closely contested affair with their knack for putting points on the scoreboard."
NFL Week 5 schedule:How to watch Week 5 NFL games
Sports Betting Dime: Lions 30.4, Patriots 24.9
The site's formula predicts that the Lions will win the game on Sunday.
Fan Duel: Lions 27, Patriots 24
Larry Rupp writes: "One victory after another is slipping through the Lions' grasp this season. Each of their three losses have come by four points or less and now they must travel to Gillette Stadium where Bill Belichick awaits. This is a different Detroit team than in years past, though, and it can pull off the small upset. The Lions are averaging a league-best 436.8 yards per game and could get Amon-Ra St. Brown and D'Andre Swift back for this one. Detroit's defense has been subpar, but New England may be forced to start their third-string QB again. Head coach Dan Campbell will have his guys ready for this one."
NFL power rankings:Philadelphia Eagles, Dallas Cowboys, New York Giants shine
Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on Twitter @Jeremy_Cluff.
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