Indianapolis Colts vs. Denver Broncos picks, predictions: Who wins NFL Week 5 game?

Jeremy Cluff
Arizona Republic
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The Indianapolis Colts and Denver Broncos play on Thursday in a game on the NFL Week 5 schedule.

Which team will get the victory?

Check out these NFL Week 5 picks and predictions for the game, which can be seen at 5:15 p.m. MST on Amazon Prime Video.

The Broncos are a 3.5-point favorite in the game.

NFL Week 5 picks, predictions:

The Arizona Republic:  Broncos 24, Colts 17

Jeremy Cluff writes: "The Broncos are 2-0 on the season at home. We think that their defense will do enough against Matt Ryan to make it 3-0 after Week 5." Take the over in Colts vs. Broncos game

Bill Speros writes: "The two senior QBs who switched teams this offseason face off in the altitude of Denver. Matt Ryan came to the Colts after 14 seasons in Atlanta. Russell Wilson landed in Colorado after 13 years with Seattle. Expect plenty of yards through the thin air of Empower Field at Mile High – as long as Nathaniel Hackett lets Russ do more than cook in the microwave."

NFL Week 5 odds:

Will Russell Wilson and the Denver Broncos beat the Indianapolis Colts in their NFL Week 5 game on Thursday Night Football?

ESPN: Broncos have a 58.5% win probability

The site's Football Power Index gives the Colts a 41% chance to win the NFL Week 5 game.

Draft Kings: Go with the Colts with the points vs. Broncos

It writes: "The Colts already have a strong run defense, and with Williams and Gordon both potentially injured, they should be able to force the Broncos to score through the air. Russell Wilson has not found consistent success this season in his passing game, so if the Colts can limit turnovers, they should be able to cover the spread on TNF."

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Sports Betting Dime: Broncos 11.4, Colts 0.9

The site's formula predicts a very low scoring game, with the Broncos getting the victory.

Fan Duel: Broncos will cover against Colts in Week 5

Larry Rupp writes: "This contest could come down to a few plays in the fourth quarter, according to the opening betting lines. ESPN's FPI backs up that outcome as well. I'm siding with the Broncos here given the home-field advantage they have working in their favor. This is a defense that feeds off the support of the crowd and continues to earn one red zone stop after another. Keep in mind quarterback Matt Ryan has also struggled on the road this season, so give me Russell Wilson's Broncos to cover."

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