San Francisco 49ers vs. Carolina Panthers picks, predictions: Who wins NFL Week 5 game?

Jeremy Cluff
Arizona Republic
View Comments

The San Francisco 49ers and Carolina Panthers play on Sunday in a game on the NFL Week 5 schedule.

Which team will get the victory?

Check out these NFL Week 5 picks and predictions for the game, which can be seen at 1:05 p.m. MST on CBS.

The 49ers are a 4.5-point favorite in the game.

NFL Week 5 picks, predictions:

The Arizona Republic: 49ers 30, Panthers 20

Jeremy Cluff writes: "Baker Mayfield and the Panthers' struggles this season will continue in a loss to the 49ers." Take the 49ers to cover vs. Panthers

Bill Speros writes: "Jimmy Garoppolo vs. Baker Mayfield. Two of the top "Almost-Elite" QBs of the 21st century meet in Charlotte. Neither expected to be with their respective teams at the end of last season. And Mayfield, for one, doesn't seem very happy in the Queen City these days. After a three-turnover performance in Week 4, he and the hometown Cats were booed lustily when Mayfield ended their chances after his fourth deflected pass of the game."

NFL Week 5 odds:

Will Christian McCaffrey and the Carolina Panthers beat the San Francisco 49ers in their NFL Week 5 game?

ESPN: Panthers have a 58.1% win probability

The site's Football Power Index gives the 49ers a 41.4% chance to win the NFL Week 5 game.

Draft Kings: Go with the Panthers with the points vs. 49ers

David Fucillo writes: "The Panthers stink, but the 49ers are coming into this game in a bad spot. Whether they beat the Rams or not on Monday, they’ll likely find themselves in an incredible physical game and in turn heading to Charlotte on a short week. The 49ers should win this game, but it could end up a lot closer than many would expect. Lean taking the points, but also consider the under."

NFL Week 5 schedule:How to watch Week 5 NFL games

Sports Betting Dime: 49ers 11.8, Panthers 8.2

The site's formula predicts that the 49ers will get a close win in a low-scoring game on Sunday.

Fan Duel: Bet Panthers with points vs. 49ers

Larry Rupp writes: "This battle could be determined within the final few possessions, according to the opening betting lines. ESPN's FPI seems to think the Panthers will emerge victorious and I believe they will at least be able to keep the score close. Carolina's woeful offense has forced people to overlook how dominant their defense has been. Young stars like Jeremy Chinn and experienced pros like Brian Burns are getting the job done. The 49ers have only scored 20 total points across two away games."

NFL power rankings:Philadelphia Eagles, Dallas Cowboys, New York Giants shine

Reach Jeremy Cluff at Follow him on Twitter @Jeremy_Cluff.

Support local journalism: Subscribe to today.

View Comments