Colts vs. Seahawks picks for NFL Week 1: Colts try to end a long losing skid in season openers
The Indianapolis Colts host the Seattle Seahawks in NFL Week 1 action Sunday (1 p.m., Fox) at Lucas Oil Stadium. The Colts are seeking their first season-opening victory since 2013.
Carson Wentz is making his debut as Colts quarterback, while Russell Wilson starts his 10th season behind center for Seattle.
The Seahawks are 3-point favorites by most sportsbooks. Many NFL and betting observers see the Colts still searching for a Week 1 win in 2022 — and if they snap their skid, it's by the the narrowest of margins.
Colts Cover 2:X-factors, bold predictions and playoffs chances
Teddy Ricketson, Draft Kings: Seahawks cover a 2.5-point spread
The pick here is the Seahawks -2.5 because even though they are on the road they are a more well-rounded team. The Seahawks offense is relatively unchanged from the 2020 season other than them bringing in Gerald Everett at tight end which is an upgrade. The Colts defense will be a tough one to start with, but the offense is going to go with Carson Wentz, who missed the preseason due to injury recovery. The best player for the Colts is running back Jonathan Taylor, but the Seahawks allowed the fifth-fewest rushing yards per game last year, so they have a chance to limit Taylor’s success and put the pressure on Wentz, which should end favorably for the Seahawks.
Gregg Rosenthal, NFL.com: Seahawks 23-17
This is not the same Colts offensive line. Left tackle Eric Fisher is trying to return from an Achilles tear and All-Pro guard Quenton Nelson has had back and foot injuries. This is also not the same Seahawks defensive line. They have the depth inside and out to rush the passer — and to test whether Carson Wentz can get rid of the ball more quickly than he did in Philadelphia. A Wentz whose mobility might be reduced coming off his own foot injury is not a Wentz I'm picking to beat quality competition.
Bill Bender, Sporting News: Seahawks 30-20
The Colts have issues at quarterback. If Carson Wentz (foot) cannot play, then Jacob Eason will make his first NFL start. Seattle allowed just 3.9 yards per carry last season, so whoever is at quarterback will be pressed to match plays with Russell Wilson. The Seahawks start off the season in style under new offensive coordinator Shane Waldron.
Emmanuel Morgan, New York Times: Seahawks cover the spread
The Colts hoped new scenery would resurrect the 2017 version of Carson Wentz, who helped lead the Eagles in the regular season on a run to a title. But a foot injury and a stint on the Covid list robbed him of valuable training camp reps with his new teammates. He’ll face a Seahawks defense that surrendered the second-most passing yards in the league to opposing teams last season but that hopes linebacker Bobby Wagner and safety Jamal Adams can turn the unit into a more consistent threat. (Adams’ 9.5 sacks last season were the most ever by a defensive back.)
Seattle will lure opponents into trying to keep up with the scoring pace of Russell Wilson, D.K. Metcalf and Tyler Lockett, as it did last year. Wentz will be the first to find out how much tougher that has become.
Brad Gagnon, Bleacher Report: Colts 27-26
The Colts were once a clear favorite in this game, and then Carson Wentz and Quenton Nelson went down and the line shifted significantly in Seattle's direction. But now, both Wentz and Nelson look as though they'll be good to go for Sunday. I'm not going to pretend Wentz is on Russell Wilson's level, but he's got better support than he used to have, and there is a chance a reunion with Frank Reich will prove his 2020 struggles were an aberration.
The Seahawks remain a huge public fave, which is probably why this line hasn't moved back toward a pick 'em. But I think that spread is for suckers right now. Indy is on Seattle's level overall, and Wentz gives them extra upside. At home, I'll take any points you'll give me with the Colts.
Pete Prisco, CBS Sports: Colts 24-23
The quarterback edge is a big one in this game for the Seahawks with Russell Wilson against Carson Wentz. But the Colts get the defensive edge, which will be the difference here. They will control Wilson and Jonathan Taylor will control the clock with his running. The Colts will win a tough, hard-fought game.
Gerry Dulac, Pittsburgh Post-Gazette: Seahawks 26-21
Since the start of the 2012 season, the Seahawks have not had a losing season. And, with few exceptions, they have been renowned fast-starters. The Colts’ attempt to start anew with Carson Wentz has been derailed with another Wentz injury. Shocking.
Matt Verderame, FanSided: Seahawks 24-21
What to make of the Colts? Tons of injuries this summer, COVID problems, and Carson Wentz. In fact, Wentz really checks all the aforementioned boxes. The Seahawks have the much better quarterback and weapons, so they win a tight one on the road.