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The injury bug continued to bite the Green Bay Packers in Week 3.

Four players, including starting wide receiver Davante Adams, were knocked out of the game and didn't return during Monday night's 38-28 victory over the Kansas City Chiefs.

Adams, who was limited in practice last week with an ankle injury sustained against Seattle in Week 2, leaped for a pass near the left sideline on the Packers' third play of the game and came down awkwardly. He apparently aggravated the high-ankle sprain on the incomplete pass and limped off the field.

He was replaced in the three-receiver lineup by Ty Montgomery.

Near the end of the first quarter, Adams was taken to the locker room.

Tight end Andrew Quarless also left and didn't return after sustaining a knee injury midway through the second quarter.

Rookie linebacker Jake Ryan was visibly upset after having to depart in the fourth quarter with a right hamstring injury.

Two plays later, linebacker Joe Thomas and defensive lineman Datone Jones collided head-on trying to tackle quarterback Alex Smith. Jones was prone on the field for several minutes before walking off. He went to the locker room and was being evaluated for a concussion.

After a relatively injury-free season in 2014, the Packers have had trouble keeping players on the field this year. The spate of injuries started early in the preseason when top receiver Jordy Nelson was lost for the year with a torn ACL.

Starting middle linebacker Sam Barrington went on season-ending injured reserve after sustaining a foot injury in the season opener at Chicago, and defensive tackle Josh Boyd went on injured reserve last week with an ankle injury sustained in Week 2.

Entering Monday's game, the Packers listed 10 players on the injury list and played without starters Morgan Burnett at safety and Bryan Bulaga at right tackle.

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Third-down woes

Kansas City entered the game having converted only three of 20 third-down tries (15 percent). Green Bay entered allowing opponents to convert 54 percent (14 of 26) of the time.

Someone was bound to change their ways.

It wasn't the Chiefs.

They failed to convert third downs on their first three series — all three-and-outs — and four times overall in the first half. They also failed to convert on their first two third-down tries of the second half, and finished the game two of 10.

Insider: Thumbs up to defense setting tone

Nickel and dime

The Packers used backup safety Chris Banjo and newly re-acquired linebacker Joe Thomas for the first time in the dime sub-package.

Banjo essentially replaced the injured Burnett, while Thomas helped linebacker Clay Matthews move back to an edge rusher after playing dime linebacker against Seattle.

Thomas, who spent the past two training camps in Green Bay after going undrafted, was signed off the Dallas practice squad one week ago to replace Boyd on the roster.

"That's why he's here," Packers coach Mike McCarthy said of Thomas. "He's an excellent player in that package."

On the sidelines

Four of the Packers' inactives against the Chiefs were injury-related, including three in the defensive secondary.

Burnett (calf), backup safety Sean Richardson (ankle) and cornerback Demetri Goodson (hamstring) all sat out Monday night. That meant some shuffling in the secondary.

Nickel cornerback Micah Hyde started in place of Burnett, who missed his second game of the season.

In the nickel package, rookie cornerback Damarious Randall was on the perimeter, with starting cornerback Casey Hayward sliding inside to the slot.

It's the same lineup the Packers went with against Chicago.

Also, undrafted rookie cornerback LaDarius Gunter was activated for the first time, replacing Goodson.

The rest of the Packers' inactives were Bulaga, guard Lane Taylor, rookie quarterback Brett Hundley and rookie tight end Kennard Backman.

Bulaga missed his second straight game with a knee injury, and backup tackle Don Barclay started in his place.

Undrafted rookie running back Alonzo Harris also was activated for the first time with starter Eddie Lacy nursing an injured ankle this week.

Hundley and Backman are the only two Packers on the 53-man roster who haven't been activated for a game this season.

Among the inactives for the Chiefs was former Packers linebacker Dezman Moses.

Extra points

• Rodgers set a franchise record by throwing five touchdowns in a game for the fourth time in his career. Brett Favre held the previous record, having done it three times.

• The Packers' second touchdown was their longest scoring drive of the season at 89 yards. The drive lasted 10 plays and consumed 5:51. Cobb's 3-yard touchdown reception from Rodgers put the Packers up by two touchdowns in the first quarter. Then, midway through the third quarter, the Packers had their shortest scoring drive of the season: a one-play, 4-yarder following Sam Shields' interception and a Rodgers-to-Cobb touchdown pass that made it 31-7.

• Including playoffs, the Packers have won 11 straight home games, the longest active home winning streak in the NFL and tied for the second-longest streak of the McCarthy era.

• The Packers are 15-8-1 at home on Monday Night Football, including 5-1 under McCarthy, and 16-3 in regular-season night games at Lambeau Field under McCarthy.

• Including playoffs, Rodgers has thrown 580 passes and 48 touchdowns at home without an interception, both NFL records. He last threw an interception at home on Dec. 2, 2012, vs. Minnesota.

• After Rodgers beat Kansas City for the first time, Cincinnati is the only NFL team he hasn't beaten as a starting quarterback.

• Kansas City's Smith broke an ignominious streak by throwing a touchdown pass to a receiver in a regular-season game for the first time since Dec. 8, 2013.

• Attendance on Monday night was 78,214, which is 219 fewer than the home opener against Seattle that set a Lambeau Field record.

rzizzo@pressgazettemedia.com or follow him on Twitter @RobertZizzo.

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