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PHOENIX – David Bakhtiari likely will miss his first NFL start on Sunday against the Arizona Cardinals.

The Green Bay Packers left tackle was downgraded to doubtful following the team’s final practice in Scottdale on Saturday. Fourth-year veteran Don Barclay likely will make his first career start at left tackle, though he played there last month when Bakhtiari left with a knee injury against Detroit and didn’t return.

Bakhtiari, who sprained his ankle in Sunday's win over Oakland, has started all 46 regular-season games at the position since the Packers drafted him in the fourth round of the 2013 NFL draft.

The Packers should have the rest of their preferred offensive line back with center Corey Linsley probable to return from his ankle injury. The only question is whether he’ll reclaim the starting job from JC Tretter, who’s started three of the Packers’ last four games in Linsley's stead.

Cornerback Sam Shields (concussion) and tight end Justin Perillo (hamstring) also were ruled out after Saturday's practice. Shields, who was originally listed as doubtful, returned to meetings this week, but remains in the concussion protocol after banging his head on the sideline during a game against Dallas on Dec. 13.

Perillo, first listed as questionable, dropped out of practice on Thursday. The Packers should still have their full complement of tight ends available with the activation of Andrew Quarless (torn MCL) from temporary injured reserve earlier this week. The sixth-year veteran hasn’t played since Week 3, though.

Defensive lineman Letroy Guion (foot) remains questionable to play against the Cardinals. He was estimated as a limited participant on Friday after not practicing on either Wednesday or Thursday. Outside linebacker Jayrone Elliott (quad) already was ruled out on Friday.

whodkiew@pressgazettemedia.com and follow him on Twitter @WesHod.

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